Figure 3 Throughout our in vitro experiments, we exposed activated ILC2s to a pharmacological concentration (250M) of melatonin as has been shown previously to be maximally effective in driving phenotypic changes in T-cells without causing toxicity (43)
Over time, this oxidative insult accumulates and diminishes both follicle number and quality, presenting as premature menopause or a suboptimal response to ovarian stimulation
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