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Importantly, this work also revealed the synaptic and behavioral abnormalities in these models of ASD [172, 173, 175] that were reversed by the selective nNOS inhibitor 7-nitroindasole [172, 173]
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Our findings build on the existing knowledge of CFTRs critical role in crypt cells 121,122 , proposing a multifaceted function of CFTR in intestinal stem cells (ISCs) that varies depending on the developmental stage
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