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Be alert to dizziness when changing positions Monitor blood pressure if possible, as dehydration can cause drops Note frequency and colour of urination throughout the day Medical considerations Adjust medication timing to minimise side effects that contribute to dehydration Consider temporary dose adjustment in consultation with your healthcare provider Discuss anti-nausea or anti-diarrhoeal medications if these symptoms are contributing to fluid loss Consider IV fluids for severe cases (requires medical intervention) When to seek medical advice Contact your healthcare provider immediately if you experience: Severe thirst that cannot be satisfied by drinking Little or no urination for 8 hours or more Dizziness or lightheadedness that impairs functioning Confusion, disorientation, or extreme fatigue Rapid heart rate or breathing Fainting or severe weakness Inability to keep fluids down due to vomiting Long-term outlook With proper management, most patients can maintain adequate hydration whilst on GLP-1 treatments

However, the mechanism through which torpor is induced and maintained remains unclear

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Any change runs through formal rulemaking that could take many months

De hecho, las guas KDIGO para el manejo de pacientes con diabetes y ERC posicionan a los arGLP-1 como segunda lnea de tratamiento y los indican para pacientes con DM2 y ERC que no han alcanzado los objetivos glucmicos individualizados a pesar del uso de metformina e iSGLT2, o en los que no pueden utilizar estos medicamentos porque liraglutida, semaglutida y dulaglutida (no se haban publicado los resultados con epfeglenatida) han demostrado beneficios cardiovasculares, especialmente entre pacientes con enfermedad cardiovascular establecida, asociado a beneficios renales favorables con una reduccin sustancial de la albuminuria y probable preservacin del FGe112, as como otras guias en pacientes con DM2 y riesgo cardiovascular alto/muy alto, como son los pacientes con ERD19,113

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