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143 In conscious SHR treated with the AT 1 receptor antagonist candesartan, Ang-(17) evoked a depressor response via activation of the AT 2 receptor, involving the bradykinin-NO cascade

Research has demonstrated that through its unique mechanism of action involving beta-3 adrenergic receptor modulation and direct interaction with adipose tissue, this peptide offers a scientifically-supported approach to metabolic support and fat oxidation enhancement

For example, in a 2003 study in mice, treatment with epitalon decreased the frequency of chromosome aberrations in bone marrow cells associated with age-related diseases such as acute myeloid leukemia and myelodysplastic syndrome.14 (In humans, these diseases primarily affect people who are over the age of 45, and more commonly those who are 65 or older.)15 16 By the studys end, epitalon increased the lifespans of the last 10% of survivors by 13.3%.14 To top things off, epitalon happens to have antioxidant properties,17 which means it can help mitigate the oxidative stress induced by reactive oxygen species, one of the chief causative factors of cellular senescence.13 Improved sleep health In a 2021 human trial involving 75 women, 0.5mg of epitalon per day was found to increase melatonin synthesis by 160% compared to placebo.22 That has positive implications for sleep health because melatonin a hormone whose levels decrease with age helps control when and how well you sleep.23 In turn, improved sleep health itself has positive implications for epitalons other therapeutic uses, as longer and higher-quality slumber is linked to better immune function, lower rates of age-related diseases (including cancer), and longer lifespans.24 That isnt to say that an epitalon dose will knock you out, only that it can help optimize your circadian rhythm

It is a game changer. Adding to the momentum is some research to support its potential in helping with gastrointestinal problems, stroke recovery, and arthritis

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The clinical translation of those findings to an oral supplement context has not been established through published human pharmacokinetic data