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Furthermore, the increased levels of tau phosphorylation were significantly reduced by the inhibition of GSK-3, CDK5, and calpain, indicating that tau kinases activated by calcium overload are directly involved in the increase of tau phosphorylation

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Existe tambm a relao com anormalidades microvasculares que provocam diminuio do fluxo sangneo e hipxia neural, alterao do metabolismo de cidos graxos, estresse oxidativo e diminuio de fatores de crescimento para os neurnios e clulas Schwann 32,33