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Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits
Its ability to reduce oxidative damage and enhance mitochondrial efficiency also provides neuroprotective benefits, which may slow the progression of neurodegenerative diseases like Alzheimers and Parkinsons
This process explains why the main function of Nrf2 is to prevent oxidative stress by inducing the production of antioxidants and why HO-1 determinedly is regulated by Nrf2 activation (Joo Choi et al., 2014)
This verification prevents using wrong compounds in research studies
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