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Why long-term use makes affordability harder GLP-1 medications require continuous administration to maintain effectiveness

(Industry coverage of Eli Lilly's December 2025 TRIUMPH-4 topline announcement, including the 28.7% body weight loss figure on 12mg, the 2.1% placebo figure, and the schedule for remaining 2026 readouts.) Eli Lilly and Company

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There was dose-related weight loss among the retatrutide groups at 36 weeks that ranged from 3.2-16.9% compared with weight loss of 3.0% in the placebo group, and 2.0% in the dulaglutide group [4]

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