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There have been no human studies

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Recently, we demonstrated that the cyclolignan PPP inhibited phosphorylation of IGF-1R without interfering with insulin receptor activity (Girnita et al, 2004), as well as it reduced phosphorylated Akt, caused apoptosis and induced tumour regression in xenografted mice

If you experience suicidal thoughts or severe mental distress, contact the 988 Suicide and Crisis Lifeline by calling or texting 988, and discontinue Zepbound until you can speak with your healthcare provider

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