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That decision belongs to the patient and their provider
For example, some studies suggest that clarithromycin might have a more pronounced effect on blood sugar when combined with certain diabetes medications
Although the PIONEER and SUSTAIN studies only examined serious adverse reactions (SAEs) for people taking semaglutide, it is possible that similar reactions could occur after taking other GLP-1 drugs
Arch Neurol 2012;69(7):836-841
What Endocrinologists and Obesity Medicine Specialists Say The Endocrine Society's 2023 clinical practice guideline on obesity pharmacotherapy states: "Pharmacotherapy for obesity should be considered an adjunct to comprehensive lifestyle intervention, not a replacement for it." The full guideline is accessible through the Endocrine Society's journal
The primary endpoint was a composite of death from cardiovascular causes, non-fatal MI or non-fatal stroke, with a significant 20% reduction in the semaglutide group versus placebo
