doi: 10.3389/fonc.2026.1834606 Received 19 March 2026 Revised 09 May 2026 Accepted 13 May 2026 Published 28 May 2026 Volume 16 - 2026 Edited by Fahui Liu, Xiamen University, China Reviewed by Armando Patrizio, Memorial Sloan Kettering Cancer Center, NY, United States Qiming Gong, Affiliated Hospital of Youjiang Medical University for Nationalities, China Hao Ling, Technical University of Munich, Germany Updates Copyright 2026 Kennedy, Thomas, DArcy, Odia, Kamdar, Pereira, Scarola, Miles, Frank, Taneja, Seetharamu and Mandal
In terms of inflammation, MC4R KO mice showed pro-inflammatory gene expression, such as TNF-alpha and IL1-beta in liver and white adipose tissue (WAT), indicating inflammation are activated in liver and WAT (Fig
Skin Elasticity & Anti-Aging Potential GH-driven increases in collagen synthesis translate to improved skin elasticity and a reduction in fine lines and wrinkles
While IV and oral NAD+ therapies can boost systemic levels, topical application offers a targeted approach delivering NAD+ precursors like niacinamide and NMN directly to the skin, where energy production, DNA repair, and antioxidant defense are most needed
By prioritizing these tools, we empower patients with knowledge about their health, fostering trust and collaboration
It supports normal nerve function and energy metabolism, and is commonly prescribed in vitamin B deficiency states and certain cases of neuropathy associated with nutritional deficiency