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Consumption of NADPH for 2-HG synthesis increases pentose phosphate pathway flux and sensitizes cells to oxidative stress

But profound, persistent weakness that worsens over weeks, particularly muscle-specific weakness that makes daily activities difficult, can indicate excessive lean tissue catabolism

For me, and again, this is subjective, it has a tangible effect in improving the recovery time from exercise

Additionally, 3 fatty acids stimulate mitochondrial biogenesis [97] by activating transcription factors such as PPAR- [98] and NRF2 [99], which improve mitochondrial proliferation and functionality

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MR = Mendelian randomization