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, by oxidative damage or membrane depolarization), immune cells may become either hyper-inflammatory (dumping toxic radicals, extracellular traps, etc

Months six through twelve bring continued improvement

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For instance, in the presence of the antibiotic metronidazole, thiaminase I substitutes the thiazolium ring of thiamine with the imidazolium ring of metronidazole, resulting in a thiamine antagonist which can inhibit TPK (160)