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Emerging evidence indicates that hepatokines, such as fibroblast growth factor (FGF)-21, selenoprotein P (SELENOP), Midbrain astrocyte-derived neurotrophic factor (MANF), Angiopoietin-like protein 3 (ANGPTL3), Fetuin-A, Adropin, ApoJ and sex hormone-binding globulin (SHBG), could regulate oxidative stress, immune responses, and apoptotic pathways, providing new insights into their broader physiological roles [10, 11]

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