It is a common form of heart failure in patients with obesity, hypertension, and metabolic syndrome, and it has become a recognized clinical target for incretin-based therapy following the STEP-HFpEF trial (semaglutide in HFpEF with obesity) and the SUMMIT trial (tirzepatide in obesity-related HFpEF)
Copyright: 2020, American Society for Clinical Investigation
injections of 100 nmol kg 1 MK-801, 100 nmol kg 1 GLP-1, 10 nmol kg 1 semaglutide, 100 nmol kg 1 GLP-1MK-801 or vehicle immediately before onset of the dark cycle at a volume of 2 ml kg 1
Abstract Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and cardiovascular disease (the most common cause of mortality in diabetes), as well as microvascular complications such as kidney disease and retinopathy
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