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There are several case reports of valproic acid initiation leading to increased seizures and encephalopathy (without hyperammonemia), resulting in cautions against using valproic acid in patients with known mitochondrial disorders like mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)
Genetic Variations (GSTM1, GSTP1 Polymorphisms) Polymorphisms in genes encoding glutathione S-transferases (GSTs) can reduce detoxification capacity and glutathione efficiency by 20-40%
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This powerful antioxidant supplement helps reduce free radical damage to body cells and decreases the formation of free radicals in the body
