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Some prescribers move patients up the dose ladder too quickly, often to get to the dose thats supposed to work. This usually causes side effects severe enough that the patient either stops the medication or has to drop back down
Making double agonists was hard enough
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221,222 Ischemic necrosis of myocardial tissue triggers biomechanical changes during cardiac contraction and relaxation, which activate myofibroblasts to produce excessive collagen
References [i] Baserga, R
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