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Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss

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Patients with type 2 diabetes should have regular cardiovascular risk assessment, and any new cardiac symptoms should prompt thorough evaluation

On the other hand, TIS can be induced by anticancer drugs and radiotherapy