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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Body composition shifts are real but modest, typically a few pounds of visceral fat reduction and improved muscle definition over months, not the dramatic scale changes seen with semaglutide or tirzepatide

Individuals on diabetes medications do not need dose changes, thyroid medication remains stable, and there are no concerns about growth hormones effects on other hormones or metabolic pathways

*Instrumental result, 33 women

Blank controls were set, in which DCFH-DA incubation was omitted

The RIP1 pathway was also shown to contribute specifically to the promotion of oxidative stress-induced necroptosis, which leads to melanocyte death