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On the molecular level, human microRNAs (miRNA) have also been identified as potential early biomarkers for indicating APAP-induced hepatotoxicity at a stage before alanine aminotransferases become elevated

Because not only does paracetamol deplete Glutathione, but it will also induce the production of NAPQI - a toxic metabolite

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When GSH regeneration is further limited by inhibition of SLC7A11 (with erastin), cell death ensues

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Think of it as being switched on or off