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[2] The bar for FDA drug approval is extremely high, and many compounds that fall short of that bar still have meaningful clinical utility under medical supervision

10.1210/en.2003-0007

Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

J Immunol 182 : 72647271 Bunnell E, Pacht ER 1993 Oxidized glutathione is increased in the alveolar fluid of patients with the adult respiratory distress syndrome

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