J Clin Invest 2024;134:e178239.ArticlePubMedPMC 113
GLP-1RAs and DPP-4is have been compared in patients with fair kidney function in previous studies, which have reported a decrease in HbA1c [23,24,25] and reduction in body weight [25]
It must be prescribed by an experienced doctor and specifically to the individuals needs to manage type 2 diabetes
4.1.4 Mortality and adverse events The available evidence demonstrates that GLP-1 RAs therapy reduces all-cause mortality in T2DM, including patients with chronic kidney disease and increased cardiovascular risk (53)
If appetite suppression fades significantly between doses or fails to appear at a given dose level, that information helps guide escalation decisions
[16] [17] However, in othersespecially those who lose weight very rapidlymenstrual cycles may become irregular or cease altogether