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Since melanin is responsible for skin color and dark spots, reducing its synthesis can promote a more even skin tone and diminish hyperpigmentation
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Mercaptoacetic acid was dimerized in the presence of trifluoroacetic acid and acetone and then reduced with lithium aluminum hydride into the linker 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid (synthetic strategy: Supplementary Fig
Posey DJ, McDougle CJ
RCOG (2011)
These same molecules were also subsequently approved for weight lossliraglutide in 2014, and semaglutide, as Wegovy, in 2021
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