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Significantly, increased production of reactive-oxygen species often takes place with the parallel accumulation of reactive nitrogen species

Chelators compete for the copper directly, so buffers containing ethylenediamine tetraacetate, and to a lesser extent citrate and some phosphate systems, will strip it

Abnormal sperm morphology and an increase in malondialdehyde (MDA) levels were observed in the 10 mg/kg treatment group, whereas the changes were more pronounced in the 20 mg/kg treatment group, which exhibited a decrease in sperm counts, abnormal sperm morphology, DNA damage, degradation of cellular tubular structures, and elevated serum LH and testosterone levels

-EC also exerted neuroprotective effects in AD [15]

Evidence for involvement of NADPH and not glutathione as the reductant