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Lab Tests That Reveal How Homocysteine Interacts With Methylation and Inflammation To understand how homocysteine is behaving, the most informative tests are: Homocysteine (plasma) SAM and SAH levels (Doctors Data Panel) Methionine B6, B12, folate Glutathione markers - identifies if macrocytosis is present CBC MMA (for functional B12 status) Histamine (as a methylation phenotype marker) Genetic markers (MTHFR, MTR, MTRR, CBS) For undermethylators, SAH and methionine are typically more revealing than homocysteine alone

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