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Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody
Brain Dev 33:512517 Sakai E, Yamanaka G, Kawashima H, Morishima Y, Ishida Y, Oana S, Miyajima T, Shinohara M, Saitoh M, Mizuguchi M (2013) A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation
Mechanism 1: Glutathione Peroxidase (GPx) - The Thyroid's HO Scavenger The glutathione peroxidase (GPx) enzyme family - particularly GPx1, GPx3, and GPx4 - uses glutathione as its essential substrate to neutralize HO in thyroid cells
Einer C, Munk DE, Park E, Akdogan B, Nagel J, Lichtmannegger J, Eberhagen C, Rieder T, Vendelbo MH, Michalke B, Wimmer R, Blutke A, Feuchtinger A, Dershwitz P, DiSpirito AM, Islam T, Castro RE, Min B-K, Kim T, Choi S, Kim D, Jung C, Lee H, Park D, Im W, Eun S-Y, Cho Y-H, Semrau JD, Rodrigues CMP, Hohenester S, Sandahl TD, DiSpirito AA, Zischka H (2023) Gastroenterology 165:187-200.e187
Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration
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