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What the Animal Research Shows This is where things get genuinely interesting

Optimal levels of vitamin B12 can be reached through vitamin injections in the doctor's office

Microbial Ecol (2011) 61:47385

Understanding the fundamental role of Intrinsic Factor and Transcobalamin II in B12 abortion, utilisation and recycling required for effective mitochondrial delivery is also vital

Gentle mixing is typically preferred over aggressive agitation for peptide solutions

Conformational instability Short duration of action and are rapidly cleared by the liver and kidneys Hard to penetrate into the tissue you need it (particularly the blood brain barrier for uses to help the brain nervous system) They breakdown in the stomach, so hard to give the peptide orally