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It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)
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Open Access J Sports Med
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This allows your digestive system to adjust to the new nutrient profile
Dose reduction remains the most reliable solution if water retention becomes genuinely bothersome
