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Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction
Resistance after CF-based NAC may be driven predominantly by the selection or enrichment of pre-existing resistant subclones or cell states, rather than by extensive therapy-induced reprogramming
This may result in a fierce cycle of oxidative stress and challenges to detoxification
Khan L, Bamji MS: Plasma carnitine levels in children with protein-calorie malnutrition before and after rehabilitation
Who should avoid Pregnant women: There isn't enough research on both the benefits and side effects of taking L-carnitine during pregnancy, so L-carnitine is best avoided during pregnancy
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