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Intracellular cysteine depletion can also be induced by sorafenib, the sole approved first-line drug for advanced HCC that inhibits the cystine-glutamate antiporter (system x c ) in addition to multiple kinases 47,48
Consequently, failure of IECs as mediators between these two major factors influencing intestinal inflammation (3) may critically contribute to IBD pathogenesis (7)
However, it is essential to monitor for any rare or severe side effects , as clinical trials are still ongoing
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