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One mechanism detail worth knowing: repeated high doses can blunt the response over time (desensitization), which is part of why dosing near the saturation point, not above it, is the common approach

The 28-day mark is not a chemical cliff, and a vial punctured twice with good technique is not meaningfully different on day 30 than on day 27

Serving as the swiftest neuroendocrine regulatory mechanism for stress response, the HPA axiss failure in feedback mechanisms leads to chronic damage through inflammation (42)

Epub 2013 Oct 12

2017 Oct;37(10):1309-1321

To assess the role of 3-AR in mediating these effects, researchers examined AOD9604 and hGH treatment in 3-KO mice