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Arabidopsis vtc2-1 accumulates only 10 to 30% of the wildtype Asc level, which results from a mutation in the GDP-l-galactose phosphorylase 1 gene, the enzyme catalyzing an intermediate step in Asc synthesis (Mller-Moul et al

Among these, there were electrophiles with warheads that target either cysteines (for example, acrylamides or chloroacetamides) or other nucleophilic residues such as lysine (for example, aldehydes or sulfonyl fluorides)

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To address this, dual treatment with IGF-1R/IR inhibitors may be the appropriate approach to avoid compensatory cross talk between IGF-1R and IR