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Given that we also demonstrated that X(PC) cleaves multiple downstream caspase substrates, this partial reduction could result from engagement of alternate caspase-mediated pathways or off-target cleavage of other protease-sensitive death effectors
doi: 10.1038/s41591-018-0222-4 119 SunY.ZhuM.ZhaoH.NiX.ChangR.SuJ.et al
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GLP-1 agonists carry a specific warning regarding medullary thyroid carcinoma risk based on rodent data, and personal or family history of this cancer type is a contraindication
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