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These results suggest that pathways other than Wnt signaling may be responsible for initiating the regenerative response of supporting cells after hair cell loss but that active Wnt signaling is both necessary and sufficient for proliferation in later stages of hair cell regeneration

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However, serum levels of IGF-1, calcium, and phosphorus were not affected in these animals, potentially explained by compensatory mechanisms that are in place to guarantee stable serum levels of these critical substances

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