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How does GLP-1 work in the body for weight loss

S., Garzon, S., Casarin, J., Franchi, M., & Ghezzi, F

Common side effects of GLP-1RAs include gastrointestinal reactions such as nausea, vomiting and diarrhea (Chin et al., 2023

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Thirdly, Ozempic slows gastric emptying, which helps to reduce post-meal blood glucose spikes

Highlights GLP-1 medicines reduce fat and liver mass more rapidly than skeletal muscle (SKM) Running performance is maintained or improved in mice on GLP-1 medicine GLP-1 medicine modifies the SKM proteome despite similar weight loss as calorie restriction Patients on GLP-1 medicine slightly reduce SKM mass but largely maintain strength Summary The large decrease in body weight with glucagon-like peptide-1 (GLP-1) medicines raises concern about a loss of lean body mass (LBM) and skeletal muscle