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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (25, 41, 62, 63)

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Zhang P, Mao C, Sun A, et al

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Along with collagen levels in your skin decreasing as you age, structural changes occur within the cartilage throughout your body