It has been hypothesized that the peptide may influence signaling cascades involving cytokine-like molecules or growth-related pathways
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Cells 3:363385 Ji Y, Chen S, Li K, Xiao X, Xu T, Zheng S (2014) Upregulated autocrine vascular endothelial growth factor (VEGF)/VEGF receptor-2 loop prevents apoptosis in haemangioma-derived endothelial cells
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However, the native molecule is rapidly degraded in circulation primarily by the serum enzyme dipeptidyl peptidase-4 (DPP-4), which cleaves at the Tyr-Ala bond at the N-terminus resulting in a biological half-life of just two to seven minutes