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The long-term weight management picture has one part that doesn't make it into most ads: stopping GLP-1 therapy is consistently associated with weight regain in clinical extension studies

10.1016/j.heares.2019.107880 17 CoatesL

Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1 (7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides

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The Psychopharmacology animal study specifically including retatrutide suggests similar central effects on alcohol motivation may extend to the triple agonist but this remains preliminary

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