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Drawbacks: Like all GLP-1s, it has side effects, with nausea and other GI problems being most common

A 2025 radiographic study found an average 7% reduction in midfacial volume for every 10 kilograms of total weight lost, with most of the change occurring in superficial facial fat pads

Per-component dose ranges in published preclinical research differ across the two compounds

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Concentration selection for topical copper peptide dosing spans a wide range in the research literature from 0.05% for sensitive-area research to 1-2% for more robust skin regeneration research