GLP-1/GIP receptor agonists mimic two hormones , as opposed to just one, which may help explain their superior effects on blood sugar control and weight loss
Obesity now affects more than a billion people worldwide, according to a study published in March in the British medical journal The Lancet.
A few are piloting outcomes-based models , where ongoing access to medication depends on participation in coaching or lifestyle change programs
Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class
Researchers noted that their study supports the results of smaller, earlier studies on GLP-1 drugs and heart failure
10.1016/j.bbalip.2007.02.012 Biochim