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While this sensation is harmless and does not mean the medication isnt working, it can contribute to needle anxiety. Bolded Lead Sentence: Removing the chill from the medication allows the liquid to enter the subcutaneous tissue (the fat layer just under the skin) more gently

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This effect occurs in approximately 15-20% of users and usually diminishes with continued use

For the spending trends, the research team looked at total payments (from patients, insurance, employers, Medicare, Medicaid and other programs) and out-of-pocket payments made directly by patients and their families