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Hold for an additional 10 seconds before removing

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The excess ROS, including superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 (Rothenberg et al., 2003), CP of 350 mg/m 2 ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Lim et al., 2010