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This weight gain is theorized to be potentially linked to an increase in adipose tissue relative to the overall body mass

For that, cells require efficient utilization of fatty acids and glucose, and such is controlled by PDK

This is just to make sure everything is okay

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Given these potential mechanisms, this study was designed to test the hypothesis that DIO mice restored to the weight and adiposity of LD controls through NNMTi treatment and LD switch 13 have a similar microbiome profile to mice continuously maintained on LD