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Newer GLP-1 receptor agonists and obesity-diabetes
The success of these drugs as a non-invasive treatment for obesity has led to an estimated decrease of 15% in bariatric surgeries
12 Meanwhile, computational design approaches are accelerating the development of PROTACs and AUTACs, enabling targeted degradation of disease-associated proteins through UPS or autophagy, respectively
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Beyond mitochondrial dysfunction, the association between apoptosis and endoplasmic reticulum (ER) stress has also been widely studied (83, 110)
& Heath, C
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