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Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity

As a result of the expected increasing use in reproductive-aged women, close monitoring and proactive pharmacovigilance are warranted [140]

Bendotti G, Montefusco L, Lunati ME, Usuelli V, Pastore I, Lazzaroni E, et al

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