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You start on a low dose for safety, to minimise potential side effects
In particular, ECL1 and ECL3, which were disordered in the previous TMD structure, are now ordered and form a -helical conformation reminiscent of the peptide-bound GLP-1R structures
That can make the body feel tense and make the moment seem bigger than it is
This does not mean retatrutide microdosing never works
Nguyen T, Wen S, Gong M, et al
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