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Radioprotection by alpha-lipoic acid palladium complex formulation (POLY-MVA) in mice

ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

How does/can this work with other Maximus Protocols

27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication

Sample analysis Samples were analyzed using an Agilent 6540 QTOF with a Jet Stream Electrospray Ionization Source (ESI) and an Agilent 1290 UHPLC (Agilent Technologies, Santa Clara, CA)

K m and V max values were defined using non-linear regression in GraphPad Prism 8.0.2