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These differences are meaningful but both formulations achieve clinically significant improvements in glycemic control

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The resulting FRP review processes have clearly defined milestones and timelines for both the regulator and the applicant, with a preliminary assessment stage which allows filtering of applications which do not meet the requirements and prevents time wastage

Other side effects may occur

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Role of GLP-1R binding kinetics The length of time that an agonist remains bound to its receptor, or residence time, is an important factor influencing the duration of drug action and a suggested driver of sustained signaling from internalized receptors 7