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demonstrated that topical GHK-Cu at concentrations as low as 0.01% stimulated collagen synthesis in human dermal fibroblast cultures, and clinical application of GHK-Cu-containing creams improved skin thickness and elasticity in photoaged skin over 12 weeks [1]

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These include the POMC-derived peptides released by neighbouring keratinocytes and the neuropeptide calcitonin gene-related peptide, substance P, and neuropeptide Y released from intramucosal free nerve endings, which are in close contact with melanocytes in the basal cell layer of the epithelium

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