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Their success in managing both diabetes and obesity has been revolutionary, with GLP-1 RAs demonstrating substantially improved efficacy over last-generation interventions

Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al

Strikingly, among the three LEO-upregulated SCFAs (acetic acid, isobutyric acid, butyric acid), only butyrate stimulated GLP-1 secretion in a concentration-dependent manner (30 M and 60 M

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However, roughly half of the people using these drugs discontinue them within 1 year