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Limitations to this study include that there were uncontrolled confounding factors, as well as bias secondary to self-selection of treatment
Shigeto M, Ramracheya R, Tarasov AI et al (2015) GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
Discussion Neuropharmaceutics represents the most promising avenue for addressing cognitive impairments among DS patients, making it the largest potential growth sector in the pharmaceutical industry (Pardridge 2007
However, despite GLP-1 agonists higher efficacy, the higher cost makes them not cost-effective [61] in some analyses when compared to older, less expensive alternatives
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